Sarvepalli Radhakrishnan was born in Tirutani on September 5, 1888 into a poor brahmin family. His father Sarvepalli Veeraswami was employed on a meagre salary in the zamindari. His mother's name was Sitamma. It was difficult for Radhakrishnan's father to educate him with a meagre income and a large family to take care.  Radhakrishnan went through most of his education on scholarships. He initially went to school in Tirutani and then to the Lutheran Mission School in Tirupati for his high school.He joined the Voorhee's College in Vellore but switched to the Madras Christian College at the age of 17.He chose philosophy as his major and attained a B.A. and M.A. in the field. He was afraid that his M.A. thesis, "The Ethics of the Vedanta" would offend his philosophy professor, Dr. A.G. Hogg. Instead, Dr. Hogg commended Radhakrishnan on doing an excellent job. Radhakrishnan's M.A. thesis was published when he was only 20.

Radhakrishnan was married to Sivakamuamma at the age of 16 while still in Vellore. Radhakrishnan accepted an Assistant Lectureship at the Madras Presidency College in 1909. While at the College, he mastered the classics of Hindu philosophy, namely the Upanishads, Bhagvad Gita, Brahmasutra, and commentaries of Sankara, Ramunuja and Madhava. He also acquainted himself with Buddhist and Jain philosophy. At the same time he read philosophical commentaries of Plato, Plotinus, Kant, Bradley, and Bergson. Later on in his life, he studied Marxism and Existentialism. 

In 1914, in a strange twist of fate, Radhakrishnan met Srinivasa Ramanujan, the mathematical genius. Srinivasa was leaving for Cambridge for studies and had come to seek Radhakrishnan's blessings because a goddess came in his dream and told him to do so before undertaking the trip. The two never met again. 

In 1918, Radhakrishnan was selected as Professor of Philosophy by the University of Mysore. By the time, Radhakrishnan had written many articles for journals of repute like The Quest, Journal of Philosophy and the International Journal of Ethics. He completed his first book "The Philosophy of Rabindranath Tagore." He believed Tagore's philosophy to be the "genuine manifestation of the Indian spirit." Radhakrishnan's second book, "The Reign of Religion in Contemporary Philosophy" was published in 1920. 

Radhakrishnan's books and articles, drew the attention of Ashutosh Mookerjee, Vice Chancellor of Calcutta University. He nominated Radhakrishnan to the prestigious George V Professor of Philosophy at the Calcutta University, 1921. In 1923, Dr. Radhakrishnan's "Indian Philosophy" was published. The book was in response to the request made by Prof. J. H. Muirhead, to write a book on Indian philosophy for the Library of Philosophy. Radhakrishnan accomplished this mammoth task by producing a systematic and readable account of Indian philosophy. The book was hailed as a "philosophical classic and a literary masterpiece." 

Radhakrishnan was called to Oxford University, England, to deliver the prestigious "Upton Lectures" on "The Hindu View of Life." The lectures were followed by an invitation to head the Department of Comparative Religion at Oxford. A philanthropist, Spalding, created a professorship for Radhakrishnan to teach Religion and Ethics at Oxford. 

Radhakrishnan used his lectures as a platform to further India's cause for freedom. He thundered, "India is not a subject to be administered but a nation seeking its soul." He would graphically describe the "shame of subjection and the lines of sorrow" apparent on every Indian's face. 

In 1931, Radhakrishnan was elected Vice Chancellor of the Andhra University. The University was in a state of stagnation. Radhakrishnan restructured the Honors and Post- Graduate teaching in Humanities and Languages, and Science and Technology Departments from scratch. By the time he left in 1936, he had transformed the University into a robust and well-recognized institution. 

In 1939, Radhakrishnan became the Vice Chancellor of the Benaras Hindu University, Uttar Pradesh, founded by Pt. Madan Mohan Malaviya. The University was under pressure from the Governor, Sir Maurice Hallet, to turn the campus into a war hospital in response to the Quit India Movement launched by Gandhiji and the Congress. Radhakrishnan rushed to Delhi and successfully persuaded the Viceroy, Lord Linlithgow, to halt the Governor's action. The Governor instead suspended financial support to the University. Radhakrishnan went on "a Begging Pilgrimage," to collect funds from sympathizers and philanthropists. When Malaviyaji retired from University work completely, the Benaras Hindu University requested Radhakrishnan's services for an indefinite period which Radhakrishnan acquiesced to. 

After independence on August 15, 1947, Radhakrishnan was requested to Chair the University Education Commission in 1948. The Radhakrishnan Committee's suggestions helped mould the education system for India's needs. 

In 1949, Dr. Radhakrishnan was appointed ambassador to the Soviet Union. The appointment raised many eyebrows because people wondered what kind of an impression Radhakrishnan, a student of idealist philosophy, would make on Joseph Stalin, an ardent communist. In 1950, Radhakrishnan was called to the Kremlin to meet with the Premier. This was rather irregular. Radhakrishnan was accompanied by Indian Embassy Minister, Rajeshwar Dayal and Soviet Foreign Minister Andrei Vyshinsky and interpreter Pavlov. Radhakrishnan told Stalin, "We had an emperor in India who, after bloody victory, renounced war and became a monk. You have waded your way to power through force. Who knows that might happen to you also." Radhakrishnan was referring to Stalin's infamous "bloody" purges. Stalin smiled and replied, "Yes, miracles do happen sometimes. I was in a theological seminary for five years!" 

On April 5, 1952, a few days before Radhakrishnan's departure for India, Stalin called on Radhakrishnan. Radhakrishnan records Stalin's face being bloated. Radhakrishnan patted him on the cheek and on the back. Stalin said, "You are the first person to treat me as a human being and not as a monster. You are leaving us and I am sad. I want you to live long. I have not long to live." Stalin died six months later. Radhakrishnan's legacy in Moscow was a firm and friendly understanding between India and the Soviet Union. A relationship which has flourished over the years and has become even stronger. 

Radhakrishnan was elected Vice-President of India in 1952. The Vice-President presides over the Rajya Sabha (Upper House) sessions, much like the Speaker does in the Lok Sabha (Lower House). Often, during a heated debate, Radhakrishnan would intervene with slokas from the sanskrit classics or quotations from the Bible to calm the charged atmosphere. Nehru commented later, "By the way in which Radhakrishnan conducted the proceedings of the Rajya Sabha, he had made the meetings of the House look like family gatherings!" 

Dr. Radhakrishnan was honored with the Bharat Ratna in 1954. Around the same time, an 883-page compilation titled "The Philosophy of Dr. Sarvepalli Radhakrishnan" was released in America. 

In 1956, Radhakrishnan's devoted wife, Sivakamuamma, passed away after sharing 50 years of married life. The couple had five daughters and a son. 

After serving two terms as Vice-President, Radhakrishnan was elected President of India in 1962. Radhakrishnan's tenure as President was marked by the disastrous Indo-China war of 1962, his state visit to the United States in 1963, the end of the Nehru-era with Nehru's death in 1964, and India's victorious performance against Pakistan in 1965 under Lal Bahadur Shastri. Radhakrishnan guided each of the Prime Ministers wisely and helped see India through those trying years safely. Radhakrishnan refused to continue for another term as President after his term ended in 1967. 

At the age of 79, Dr. Radhakrishnan returned to Madras in May 1967 to a warm homecoming. He spent his last years happily at his house "Girija" in Mylapore, Madras. 

Dr. Radhakrishnan died on April 17, 1975.